IL-12 p70
IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-γ-producing Th1 cells. Recombinant Human IL-12 p70, derived from HEK293 cells, is a heterodimeric glycoprotein consisting of disulfide-linked p35 and p40 subunits (503 total amino acid residues) . The calculated molecular weight of Human IL-12 p70 is 57.2 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of 65-70 kDa based on SDS-PAGE gel, under non-reducing conditions.
Product Specifications
Synonyms
Interleukin-12, NKSF, CTL Maturation Factor (TCMF), Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF
NCBI Gene ID
3592
UniProt
P29460
Accession Number
NP_002178.2
Accession Number mRNA
NM_002187.2
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to increase IFN-γ production by anti-TCR mAb-stimulated PBMCs.
Length
503
Form
Lyophilized
Molecular Weight
65-70 kDa
Host or Source
CHO cells
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
NCOA4 (Nuclear Receptor Coactivator 4, ARA70, DKFZp762E1112, ELE1, PTC3, RFG) (MaxLight 650)
Phospho-FAK (Tyr861) Polyclonal Antibody, HRP Conjugated
NEUROD2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)