IL-12
IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues) .
Product Specifications
Synonyms
Interleukin-12, NKSF, CTL Maturation Factor (TCMF), Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF
NCBI Gene ID
P35: 3592; p40: 3593
UniProt
P35: P29459; p40: P29460
Accession Number
P35: NP_000873.2; p40: NP_002178.2
Accession Number mRNA
P35: NM_000882.4; p40: NM_002187.3
Chromosomal Location
3q25.33-q26
Reactivity
Human
Cross Reactivity
Monkley, Mouse, Human, Leech
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Length
503
Form
Lyophilized
Molecular Weight
75 kDa
Host or Source
CHO cells
Frequently Asked Questions
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