IGF-BP2
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Product Specifications
Synonyms
IGFBP2; IBP2; IGF-BP53
NCBI Gene ID
3485
UniProt
P18065
Accession Number
NP_000588.2
Accession Number mRNA
NM_000597
Chromosomal Location
2q33-q34
Reactivity
Human
Cross Reactivity
Mouse
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
Length
289
Form
Lyophilized
Molecular Weight
31.5 kDa
Host or Source
Insect cells
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