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IFNA2 / Interferon alpha 2 Protein (hFc Tag)

IFNA2 (Interferon Alpha 2) is a Protein Coding gene. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Type I Interferons (IFNs) are well-known cytokines that exert antiviral activity, antitumor activity, and immunomodulatory effects. Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. Among the IFN-α genes, a total of 28 different sequence variants have been described. The three principal subtypes of IFNα-2 are designated α-2a, α-2b, and α-2c. IFNα-2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant.

Product Specifications

Synonyms

If1ai7 Protein; Ifa2 Protein; Ifna2 Protein

Accession Number

P01573

Reactivity

Mouse

Cross Reactivity

Mouse

Label

HFc-Tag

Assay Protocol

See Datasheet send with the product

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

> 95 % as determined by SDS-PAGE

Bioactivity

1. Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV) . The ED50 for this effect is 1-8 ng/mL. 2. Immobilized Mouse IFNAR1 His at 2 μg/mL (100 μL/well) can bind Mouse Interferon alpha 2/IFNA2 hFc. The EC50 of Mouse Interferon alpha 2/IFNA2 hFc is 10-80 ng/mL.

Length

427

Form

Lyophilized

Buffer

PBS, pH 7.4

Reconstitution

See Datasheet

Molecular Weight

52 kDa (glycosylated monomer)

Storage Conditions

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Host or Source

HEK 293 cells

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