IFN lambda2 (IL-28A)
IFN lambda-1, -2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas uses a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14) . Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. Recombinant murine IFN-lambda2 is a 19.8 kDa protein containing 175 amino acid residues.
Product Specifications
Synonyms
IL28A; IFNL2; IL-28A
NCBI Gene ID
282616
UniProt
Q8IZJ0
Accession Number
NP_742150.1
Accession Number mRNA
NM_172138
Chromosomal Location
19q13.13
Reactivity
Human
Cross Reactivity
Human
Sequence
PVARLHGALP DARGCHIAQF KSLSPQELQA FKRA KDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.3-0.5 ng/ml.
Length
174
Form
Lyophilized
Molecular Weight
19.6 kDa
Host or Source
E. coli
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
50180126 3x 1.0µg DNA
VPS33A CRISPRa sgRNA lentivector (set of three targets)(Rat)
Sign In for Pricing
View Details 