ICAM-1
ICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. ICAM-1 is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major human rhinovirus receptor. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. The human ICAM-1 gene codes for a 505 amino acid transmembrane glycoprotein containing a 29 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 453 amino acid extracellular domain. Recombinant human ICAM-1 is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under reducing conditions.
Product Specifications
Synonyms
ICAM1; BB2; CD54; P3.58
NCBI Gene ID
3383
UniProt
P05362
Accession Number
NP_000192.2
Accession Number mRNA
NM_000201
Chromosomal Location
19p13.3-p13.2
Reactivity
Human
Cross Reactivity
Human, Bacteria
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
ICAM-1 supported the adhesion of more than 50% PMA-stimulated HSB2 cells to plates coated at 25μg/ml ICAM-1 concentration.
Length
453
Form
Lyophilized
Molecular Weight
49.5 kDa
Host or Source
CHO cells
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