GM-CSF
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues.
Product Specifications
Synonyms
Csf2; Gmcsf; Gm-csf
NCBI Gene ID
116630
UniProt
P48750
Accession Number
NP_446304
Accession Number mRNA
NM_053852.1
Chromosomal Location
10q22
Reactivity
Rat
Cross Reactivity
Mouse, Rat, Human
Sequence
MAPTRSPNPV TRPWKHVDAI KEALSLLNDM RALENEKNED VDIISNEFSI QRPTCVQTRL KLYKQGLRGN LTKLNGALTM IASHYQTNCP PTPETDCEIE VTTFEDFIKN LKGFLFDIPF DCWKPVQK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Length
128
Form
Lyophilized
Molecular Weight
14.5 kDa
Host or Source
E. coli
Frequently Asked Questions
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