GM-CSF
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant murine GM-CSF is a 14.2 kDa globular protein consisting of 125 amino acid residues.
Product Specifications
Synonyms
Granulocyte Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-alpha
NCBI Gene ID
12981
UniProt
P01587
Accession Number
NP_034099.2
Accession Number mRNA
NM_009969.4
Chromosomal Location
11 B1.3; 11 29.5 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Length
125
Form
Lyophilized
Molecular Weight
14.2 kDa
Host or Source
E. coli
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