GITR Protein (His & AVI Tag), Biotinylated
GITR, also known as TNFRSF18 (CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
Product Specifications
Synonyms
AITR Protein; CD357 Protein; ENERGEN Protein; GITR Protein; GITR-D Protein; UNQ319/PRO364 Protein
Accession Number
NP_683700.1
Reactivity
Human
Cross Reactivity
Human
Label
His-/AVI-Tag
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 95 % as determined by SDS-PAGE.
Bioactivity
Immobilized Human GITRL mFc at 2 μg/mL (100 μL/well) can bind Human GITR, Biotinylated, the EC50 is 15-90 ng/mL.
Length
162
Form
Lyophilized or frozen liquid
Buffer
PBS, pH 7.4
Reconstitution
See Datasheet
Molecular Weight
29 kDa (glycosylated)
Storage Conditions
Host or Source
HEK 293 cells
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