GITR / TNFRSF18 Protein (ECD, His Tag)
GITR, also known as TNFRSF18 (CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
Product Specifications
Synonyms
AITR Protein; Gitr Protein; Tnfrsf18 Protein
Accession Number
NP_033426.1
Reactivity
Mouse
Cross Reactivity
Mouse
Label
His-Tag
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 95 % as determined by SDS-PAGE.
Bioactivity
Data not available
Length
140
Form
Lyophilized or frozen liquid
Buffer
PBS, pH 7.4
Reconstitution
See Datasheet
Molecular Weight
15.5 kDa
Storage Conditions
Host or Source
HEK 293 cells
Frequently Asked Questions
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