GH1 Protein
Growth hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin. It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretary granules. The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones-GH-releasing hormone (GHRH) and somatostatin (SST) - as well as by signals from the periphery - ghrelin and leptin. The human GH cDNA encodes a 217 amino acid (aa) residue precursor protein with a 26 aa putative signal peptide. By alternative splicing, at least four isoforms of GH have been identified.
Product Specifications
Synonyms
GH Protein; GH-N Protein; GHB5 Protein; GHN Protein; hGH-N Protein; IGHD1A Protein; IGHD1B Protein; IGHD2 Protein
Accession Number
P01241
Reactivity
Human
Cross Reactivity
Human
Assay Protocol
See Datasheet send with the product
Endotoxin
Please contact us for more information.
Purity
≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
Bioactivity
Measured by its ability to induce GH pathway activation in a Luciferase receptor Assay System. The ED50 for this effect is 3-25 ng/mL.
Length
191
Form
Lyophilized or frozen liquid
Buffer
PBS, pH 7.4
Reconstitution
See Datasheet
Molecular Weight
22.1 kDa
Storage Conditions
Host or Source
E.coli
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