GDF-7
GDF-7 belongs to the TGF-β superfamily of growth and differentiation factors. It is expressed selectively by roof plate cells that are located in the developing embryonic central nervous system, and has been shown to influence the neuronal identity of cells within the central nervous system. GDF-7 has also been implicated in the formation, maintenance, and repair of certain cartilage and ligament tissue. Recombinant human GDF-7 is a 28 kDa disulfide linked homodimer containing two 129 amino acid residues.
Product Specifications
Synonyms
GDF7; BMP12
NCBI Gene ID
151449
UniProt
Q7Z4P5
Accession Number
NP_878248.2
Accession Number mRNA
NM_182828.2
Chromosomal Location
2p24.1
Reactivity
Human
Cross Reactivity
Human
Sequence
TALAGTRTAQ GSGGGAGRGH GRRGRSRCSR KPLHVDFKEL GWDDWIIAPL DYEAYHCEGL CDFPLRSHLE PTNHAIIQTL LNSMAPDAAP ASCCVPARLS PISILYIDAA NNVVYKQYED MVVEACGCR
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells.
Length
129
Form
Lyophilized
Molecular Weight
28 kDa
Host or Source
E. coli
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