GDF-5 (BMP-14/CDMP-1)
GDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. GDF-5 produced in E.Coli is a homodimer, non-glycosylated, polypeptide chain containing 2 x 120 amino acids and having a total molecular mass of 26.8 Dalton.
Product Specifications
Synonyms
GDF5; OS5; LAP4; BMP14; CDMP1; SYNS2
NCBI Gene ID
8200
UniProt
P43026
Accession Number
NP_000548
Accession Number mRNA
NM_000557
Chromosomal Location
20q11.2
Reactivity
Human
Cross Reactivity
Human
Sequence
APLATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
Purity
> 98% by SDS-PAGE & RP-HPLC
Bioactivity
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 µg/ml.
Length
120
Form
Lyophilized
Molecular Weight
26.8 kDa
Host or Source
E. coli
Frequently Asked Questions
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