FGF-8B (Animal Free)
FGF-8 (FGF-8b) is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical, unlike human and mouse FGF-8E and F, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant Human/Murine FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues.
Product Specifications
Synonyms
FGF8; AIGF; KAL6; FGF-8; HBGF-8
NCBI Gene ID
2253
UniProt
P55075
Accession Number
NP_149355
Accession Number mRNA
NM_033165
Chromosomal Location
10q24
Reactivity
Human/Murine
Sequence
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 97% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED50 for this effect is 2.0-4.0 ng/ml.
Length
193
Form
Lyophilized
Molecular Weight
22.4 kDa
Host or Source
E. coli
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