FGF8a / FGF-8a Protein
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.
Product Specifications
Synonyms
AIGF Protein; FGF-8 Protein; FGF8 Protein; HBGF-8 Protein; HH6 Protein; KAL6 Protein
Accession Number
NP_149355.1
Reactivity
Human
Cross Reactivity
Human
Assay Protocol
See Datasheet send with the product
Endotoxin
Please contact us for more information.
Purity
> 95 % as determined by SDS-PAGE.
Bioactivity
Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.8-3.3 μg/mL.
Length
183
Form
Lyophilized
Buffer
20 mM Tris, 500 mM NaCl, pH 8.5.
Reconstitution
See Datasheet
Molecular Weight
21.3 kDa
Storage Conditions
Host or Source
E.coli
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