FGF-6 (Animal Free)
FGF-6 is a secreted, heparin-binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4. Recombinant Human FGF-6 is an 18.7 kDa protein consisting of 168 amino acid residues.
Product Specifications
Synonyms
FGF6; HST2; HBGF-6
NCBI Gene ID
2251
UniProt
P10767
Accession Number
NP_066276
Accession Number mRNA
NM_020996
Chromosomal Location
12p13
Reactivity
Human
Cross Reactivity
Human
Sequence
GTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM TVTHFLPRI
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Length
168
Form
Lyophilized
Molecular Weight
18.7 kDa
Host or Source
E. coli
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