FGF21 Protein (His Tag)
Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
Product Specifications
Synonyms
Fgf21 Protein; Fgf8c Protein; UNQ3115/PRO10196 Protein
Accession Number
NP_061986.1
Reactivity
Human
Cross Reactivity
Human
Label
His-Tag
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
> 95 % as determined by SDS-PAGE
Bioactivity
Length
188
Form
Lyophilized
Buffer
50 mM Tris, 10 % glycerol, 0.05 % Brij 35, pH 8.0
Reconstitution
See Datasheet
Molecular Weight
23 kDa
Storage Conditions
Host or Source
E.coli
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