FGF-21
FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes. Recombinant human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.
Product Specifications
Synonyms
FGF21
NCBI Gene ID
26291
UniProt
Q9NSA1
Accession Number
NP_061986.1
Accession Number mRNA
NM_019113
Chromosomal Location
19q13.1-qter
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 90% by SDS-PAGE & HPLC analyses
Bioactivity
FGF-21, in the absence of betaKlotho, shows weak activity of thymidine uptake by BaF3 cells expressing FGF receptors.
Length
182
Form
Lyophilized
Molecular Weight
19.5 kDa
Host or Source
E. coli
Frequently Asked Questions
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