FGF-21
FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes. Recombinant human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.
Product Specifications
Synonyms
FGF21
NCBI Gene ID
26291
UniProt
Q9NSA1
Accession Number
NP_061986.1
Accession Number mRNA
NM_019113
Chromosomal Location
19q13.1-qter
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 90% by SDS-PAGE & HPLC analyses
Bioactivity
FGF-21, in the absence of betaKlotho, shows weak activity of thymidine uptake by BaF3 cells expressing FGF receptors.
Length
182
Form
Lyophilized
Molecular Weight
19.5 kDa
Host or Source
E. coli
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