Exodus-2 (CCL21)
Exodus-2 is a CC chemokine that can signal through the CCR7 receptor. It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. Recombinant murine Exodus-2 is a 12.0 kDa protein containing 110 amino acid residues.
Product Specifications
Synonyms
Ccl21a; ALP; SLC; plt; CKb9; Tca4; 6Ckine; Scya21; 6CKBAC2; SCYA21a; Scya21b; AW987545
NCBI Gene ID
18829
UniProt
P84444
Accession Number
NP_035254
Accession Number mRNA
NM_011124
Chromosomal Location
4 A5; 4 13.3 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse, Monkey, Leech, Rat
Sequence
SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FLPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract total murine T cell population using a concentration range of 10.0-100.0 ng/ml.
Length
110
Form
Lyophilized
Molecular Weight
12.0 kDa
Host or Source
E. coli
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