Exodus-2 (CCL21)
Exodus-2 is a CC chemokine that signals through the CCR7 receptor. It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. Recombinant human Exodus-2 is a 12.2 kDa protein containing 111 amino acid residues.
Product Specifications
Synonyms
CCL21; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21
NCBI Gene ID
6366
UniProt
O00585
Accession Number
NP_002980
Accession Number mRNA
NM_002989
Chromosomal Location
9p13
Reactivity
Human
Cross Reactivity
Monkey, Mouse, Human, Leech, Pig
Sequence
SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCR KTERSQTPKG P
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract total lymphocyte population using a concentration range of 10.0-100.0 ng/ml.
Length
111
Form
Lyophilized
Molecular Weight
12.2 kDa
Host or Source
E. coli
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