Eotaxin-2 (CCL24)
Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemo attracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multi potential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation) . Recombinant human Eotaxin-2 is an 8.8 kDa protein containing 78 amino acid residues.
Product Specifications
Synonyms
CCL24; Ckb-6; MPIF2; MPIF-2; SCYA24
NCBI Gene ID
6369
UniProt
O00175
Accession Number
NP_002982.2
Accession Number mRNA
NM_002991
Chromosomal Location
7q11.23
Reactivity
Human
Cross Reactivity
Mouse, Human, Bacteria
Sequence
VVIPSPCCMF FVSKRIPENR VVSYQLSSRS TCLKGGVIFT TKKGQQFCGD PKQEWVQRYM KNLDAKQKKA SPRARAVA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract using human peripheral blood eosinophils using a concentration of 50-100 ng/ml.
Length
78
Form
Lyophilized
Molecular Weight
8.8 kDa
Host or Source
E. coli
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