Eotaxin-2
Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation) . Recombinant murine Eotaxin-2 is an 10.3 kDa protein containing 93 amino acid residues.
Product Specifications
Synonyms
Ccl24; CKb-6; MPIF-2; Scya24
NCBI Gene ID
56221
UniProt
Q9JKC0
Accession Number
NP_062523.1
Accession Number mRNA
NM_019577
Chromosomal Location
5; 5 G1
Reactivity
Mouse
Cross Reactivity
Mouse, Human
Sequence
VTIPSSCCTS FISKKIPENR VVSYQLANGS ICPKAGVIFI TKKGHKICTD PKLLWVQRHI QKLDAKKNQP SKGAKAVRTK FAVQRRRGNS TEV
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract murine lymphocytes using a concentration range of 10-100 ng/ml
Length
93
Form
Lyophilized
Molecular Weight
10.3 kDa
Host or Source
E. coli
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