Endostatin
Endostatin is a naturally occurring 20 kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant human Endostatin is a 20.2 kDa protein consisting 184 amino acid residues.
Product Specifications
Synonyms
COL18A1; KS; KNO; KNO1
NCBI Gene ID
80781
UniProt
P39060
Accession Number
NP_085059
Accession Number mRNA
NM_030582
Chromosomal Location
21q22.3
Reactivity
Human
Cross Reactivity
Human
Sequence
MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
98% by SDS-PAGE & HPLC analyses
Bioactivity
Measured by its ability to inhibit HUVEC migration.
Length
184
Form
Lyophilized
Molecular Weight
20.2 kDa
Host or Source
E. coli
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