What is the catalog number for DKK-1 Protein (His Tag)?

The catalog number for DKK-1 Protein (His Tag) is M60-079-L50.

What sizes are available for DKK-1 Protein (His Tag)?

DKK-1 Protein (His Tag) is available in the following size(s): 50 µg.

Is DKK-1 Protein (His Tag) in stock?

DKK-1 Protein (His Tag) is currently made to order / not held in immediate stock. Contact us for lead time.

Are there any special shipping requirements for DKK-1 Protein (His Tag)?

DKK-1 Protein (His Tag) is requires dry ice shipping.

DKK-1 Protein (His Tag)

Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

Product Specifications

Synonyms

DKK-1 Protein; SK Protein; UNQ492/PRO1008 Protein

Accession Number

NP_034181.2

Reactivity

Mouse

Cross Reactivity

Mouse

Label

His-Tag

Assay Protocol

See Datasheet send with the product

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

Bioactivity

Measured by its ability to inhibit recombinant rmWnt3a induced alkaline phosphatase production by C3H10T 1/2 cells. The ED50 for this effect is 0.05-0.3 μg/mL.

Length

252

Form

Lyophilized

Buffer

PBS, pH 7.4

Reconstitution

See Datasheet

Molecular Weight

27.6 kDa

Storage Conditions

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.