CXCL10 / Crg-2 Protein

(C-X-C motif) ligand (CXCL) 10 (CXCL10) belongs to the ELR (-) CXC subfamily chemokine. CXCL10/IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10/IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease and ophthalmopathy), or systemic (such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, mixed cryoglobulinemia, Sjögren syndrome, or systemic sclerosis) . CXCL10/IP-10 is secreted by several cell types including endothelial cells, fibroblasts, keratinocytes, thyrocytes, preadipocytes, etc. Determination of high level of CXCL10/IP-10 in peripheral fluids is therefore a marker of host immune response.

Product Specifications

Synonyms

C7 Protein; crg-2 Protein; gIP-10 Protein; IFI10 Protein; INP10 Protein; IP-10 Protein; mob-1 Protein; SCYB10 Protein

Accession Number

NP_001556.2

Reactivity

Human

Cross Reactivity

Human

Assay Protocol

See Datasheet send with the product

Endotoxin

Please contact us for more information.

Purity

> 90 % as determined by SDS-PAGE

Bioactivity

Data not available

Length

Form

Lyophilized

Buffer

PBS, pH 7.4

Reconstitution

See Datasheet

Molecular Weight

9 kDa

Storage Conditions

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.