CTACK/ CCL27
CTACK is a keratinocyte-derived CC chemokine which signals through the CCR10 receptor. Both CTACK and CCR10 are expressed in normal and irritated epithelial cells. CTACK selectively attracts CLA+ T-cells and directs them into the skin. CTACK contains the four highly conserved cysteine residues present in most CC chemokines. The mature protein contains 88 amino acid residues. Recombinant murine CTACK is a 10.9 kDa protein containing 95 amino acid residues.
Product Specifications
Synonyms
CCL27
NCBI Gene ID
20301
UniProt
Q9Z1X0
Accession Number
NP_035466.1
Accession Number mRNA
NM_011336.1
Chromosomal Location
4 A5; 4 13.3 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
LPLPSSTSCC TQLYRQPLPS RLLRRIVHME LQEADGDCHL QAVVLHLARR SVCVHPQNRS LARWLERQGK RLQGTVPSLN LVLQKKMYSN PQQQN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human peripheral blood lymphocytes using a concentration range of 10.0-100 ng/ml.
Length
95
Form
Lyophilized
Molecular Weight
10.9 kDa
Host or Source
E. coli
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