Cardiotrophin-1
CT-1 is a member of the IL-6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL-11, IL-6 and possibly NNT-1/BCSF-3. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations. Recombinant murine Cardiotrophin-1 is a 21.3 kDa protein consisting of 202 amino acid residues.
Product Specifications
Synonyms
Ctf1; CT-1
NCBI Gene ID
13019
UniProt
Q60753
Accession Number
NP_031821
Accession Number mRNA
NM_007795
Chromosomal Location
7; 7 F3
Reactivity
Mouse
Cross Reactivity
Human, Rat, Mouse
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Length
202
Form
Lyophilized
Molecular Weight
21.3 kDa
Host or Source
E. coli
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