BTC / Betacellulin Protein (His & Fc Tag)
Betacellulin (BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1/epidermal growth factor receptor (EGFR), neu/ErbB-2/HER2, ErbB-3/HER3 and ErbB-4/HER4) . Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of about 62-111 amino acid residues. Secondary Structure: 6% helical (1 helices; 3 residues) 36% beta sheet (5 strands; 18 residues) . BTC was originally identified as a growth-promoting factor in mouse pancreatic β-cell carcinoma cell line and has since been identified in humans. It plays a role in the growth and development of the neonate and/or mammary gland function. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Product Specifications
Synonyms
Bcn Protein; Btc Protein
Accession Number
NP_031594.1
Reactivity
Mouse
Cross Reactivity
Mouse
Label
HFc-Tag/His-Tag
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
> 90 % as determined by SDS-PAGE
Bioactivity
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 2-10 ng/mL.
Length
335
Form
Lyophilized or frozen liquid
Buffer
PBS, pH 7.4
Reconstitution
See Datasheet send with the product
Molecular Weight
38 kDa (Monomer)
Storage Conditions
Host or Source
HEK 293 cells
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