BRAK (CXCL14)
Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.
Product Specifications
Synonyms
CXCL14; KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14
NCBI Gene ID
9547
UniProt
O95715
Accession Number
NP_004878.2
Accession Number mRNA
NM_004887.4
Chromosomal Location
5q31
Reactivity
Human
Cross Reactivity
Mouse, Human, Bacteria
Sequence
SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIITTKS VSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
98% by SDS-PAGE & HPLC analysis
Bioactivity
Determined by it's ability to chemoattract activated monocytes using a concentration range of 1.0-10.0 ng/ml.
Length
77
Form
Lyophilized
Molecular Weight
9.4 kDa
Host or Source
E. coli
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