BMP-4
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. This E.coli derived murine BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits which correspond to amino acids 303-408 of the full length BMP-4 precursor.
Product Specifications
Synonyms
Bmp4; bone morphogenetic protein 4; Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1
NCBI Gene ID
12159
UniProt
P21275
Accession Number
NP_031580
Accession Number mRNA
NM_007554
Chromosomal Location
14 C1; 14 15.0 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
KKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
Assay Protocol
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
>98% by SDS-PAGE & HPLC analysis
Bioactivity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-15 ng/ml.
Length
106
Form
Lyophilized
Buffer
10mM Citric Acid
Reconstitution
10mM Citric Acid
Molecular Weight
23.9 kDa
Storage Conditions
Host or Source
E. coli
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