BMP-4
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.
Product Specifications
Synonyms
BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS7
NCBI Gene ID
652
UniProt
P12644
Accession Number
NP_001193
Accession Number mRNA
NM_001202
Chromosomal Location
14q22-q23
Reactivity
Human
Cross Reactivity
Human, Mouse, Rat
Sequence
HHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR
Purity
>97% by SDS-PAGE and HPLC anaylsis
Bioactivity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml.
Length
113
Form
Lyophilized
Molecular Weight
25,6 kDa
Host or Source
HeLa cells
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