BMP-4
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.
Product Specifications
Synonyms
BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
NCBI Gene ID
652
UniProt
P12644
Accession Number
NP_001193
Accession Number mRNA
NM_001202
Chromosomal Location
14q22-q23
Reactivity
Human
Cross Reactivity
Human, Mouse, Rat
Sequence
SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAI VQT LVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR.
Purity
>95% by SDS-PAGE
Bioactivity
Length
116
Form
Lyophilized
Buffer
2XS PBS + 6% EtOH
Reconstitution
2XS PBS + 6% EtOH
Molecular Weight
26,2 kDa
Host or Source
CHO cells
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