BMP-4

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.

Product Specifications

Synonyms

BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6

NCBI Gene ID

652

UniProt

P12644

Accession Number

NP_001193

Accession Number mRNA

NM_001202

Chromosomal Location

14q22-q23

Reactivity

Human

Cross Reactivity

Human, Mouse, Rat

Sequence

SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAI VQT LVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR.

Purity

>95% by SDS-PAGE

Bioactivity

The ED50, as calculated by Alkaline phosphatase activity induced in ATDC-5 cells is 15ng/ml corresponding to a specific activity which is 6.7 x 10^4 units/mg.