What is the catalog number for BMP-2?

The catalog number for BMP-2 is 200-002-L500.

What sizes are available for BMP-2?

BMP-2 is available in the following size(s): 500 µg.

BMP-2 is currently made to order / not held in immediate stock. Contact us for lead time.

BMP-2

Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein with an apparent molecular weight of 26 kDa. BMP-2 regulates similarly to its nearest homologue BMP-4 diverse fundamental processes during embryonic development: BMP-2 and other BMP proteins have great potential for medical therapeutic applications, in particular because they allow or at least accelerate the ossification of extensive bone lesions. The amino acid sequence of recombinant human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector. BMP-2 is a heparin binding protein.

Product Specifications

Synonyms

Bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6

NCBI Gene ID

650

UniProt

P12643

Accession Number

NP_001191

Accession Number mRNA

NM_001200

Chromosomal Location

20p12

Reactivity

Human/Murine/Rat

Cross Reactivity

Human

Sequence

MQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Assay Protocol

The lyophilized BMP-2 is best soluble in 50 mM acetic acid at a concentration of 0.1mg/ml but should be also soluble in most aqueous buffers when the pH is below 6.0.

Endotoxin

< 0.1 ng per µg of BMP-2

Purity

> 95% by SDS-PAGE

Bioactivity

Measured by the ability of BMP-2 to induce alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 0.3-0.8 µg/ml.

Length

115

Form

Lyophilized

Buffer

50 mM acetic acid

Reconstitution

50mM acetic acid

Molecular Weight

26.0 kDa

Storage Conditions

Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted BMP-2 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles!