BDNF (Animal Free)
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.
Product Specifications
Synonyms
BDNF
NCBI Gene ID
627
UniProt
P23560
Accession Number
NP_733931.1
Accession Number mRNA
NM_170735.5
Chromosomal Location
11p13
Reactivity
Human/Murine/Rat
Cross Reactivity
Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat, Human, Tadpole
Sequence
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Length
119
Form
Lyophilized
Molecular Weight
27.0 kDa
Host or Source
E.coli
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