BDNF
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.
Product Specifications
Synonyms
BDNF
NCBI Gene ID
627
UniProt
P23560
Accession Number
NP_733931.1
Accession Number mRNA
NM_170735.5
Chromosomal Location
11p13
Reactivity
Human
Cross Reactivity
Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat, Human, Tadpole
Sequence
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Length
119
Form
Lyophilized
Molecular Weight
27.0 kDa
Host or Source
E. coli
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