BD-2 (SAP1)
Human ß-defensin-2 (BD-2) is an antimicrobial peptide which belongs to the distinct family of ß-defensins. Recent studies have shown that the ß-defensins are present in the human airways and may be relevant to the pathogenesis of cystic fibrosis lung disease. Human BD-2 is a 4.3 kDa protein containing 43 amino acid residues.
Product Specifications
Synonyms
DEFB4A; BD-2; SAP1; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102
NCBI Gene ID
1673
UniProt
O15263
Accession Number
NP_004933.1
Accession Number mRNA
NM_004942.2
Chromosomal Location
8p23.1
Reactivity
Human
Cross Reactivity
Human
Sequence
GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract immature dendritic cells using a concentration of 10-100 ng/ml.
Length
41
Form
Lyophilized
Molecular Weight
4.3 kDa
Host or Source
E. coli
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