BAFF receptor, soluble

BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B) . BAFF-R/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFF-R is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFF-R protein.

Product Specifications

Synonyms

TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin

NCBI Gene ID

115650

UniProt

Q96RJ3

Accession Number

NP_443177

Accession Number mRNA

NM_052945

Chromosomal Location

22q13.1-q13.31

Reactivity

Human

Cross Reactivity

Mouse

Sequence

MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 95% by SDS-PAGE & HPLC analyses

Bioactivity

Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0 μg/ml in the presence of 1.0 μg/ml of human soluble BAFF.