Arginine Deiminase (ADI)
Arginine Deiminase (ADI) is a microbial enzyme from Mycoplasma produced in E.coli. It has high affinity to L-arginine and hydrolyzes L-arginine to citrulline and ammonia. Low concentrations of ADI have been shown to inhibit proliferation in certain cultured cells by arresting the cell cycle in G (1) and/or S phase. Higher concentrations of ADI lead to subsequent apoptosis. Recombinant Mycoplasma Arginine Deiminase is a 46.3 kDa protein consisting of 409 amino acids.
Product Specifications
Synonyms
ADI
UniProt
P23793
Accession Number
CAA38080.1
Accession Number mRNA
AF182646.1
Reactivity
Mycoplasma
Sequence
Assay Protocol
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 97% by SDS-PAGE & HPLC analyses
Bioactivity
Measured by its ability to induce apoptosis in Jurkat cells using a concentration of 100-150 ng/ml.
Length
409
Form
Lyophilized
Buffer
2mM Sodium Phosphate, pH 7.5 + 0.2mM DTT
Reconstitution
Water
Molecular Weight
46.3 kDa
Storage Conditions
Host or Source
E. coli
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