What is the catalog number for Activin-A?

The catalog number for Activin-A is 100-310-L500.

What sizes are available for Activin-A?

Activin-A is available in the following size(s): 500 µg.

Is Activin-A in stock?

Activin-A is currently made to order / not held in immediate stock. Contact us for lead time.

Activin-A

Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.

Product Specifications

Synonyms

INHBA; EDF; FRP

NCBI Gene ID

3624

UniProt

P08476

Accession Number

NP_002183.1

Accession Number mRNA

NM_002192.2

Chromosomal Location

7p15-p13

Reactivity

Human/Mouse/Rat

Cross Reactivity

Chicken, Dog, Frog, Mouse, Rat, Human, Leech

Sequence

GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 97% by SDS-PAGE & HPLC analyses

Bioactivity

The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.