Recombinant Phospho-BRD2 (S37) Monoclonal Antibody
Product Specifications
Background
Brd2 is a highly conserved member of the BET subfamily of bromodomain proteins that contain two tandem N-terminal bromodomains and a single C-terminal extra-terminal (ET) domain. In addition to its involvement in guiding the expression of cell cycle genes through its binding to multiple E2Fs, Brd2 has been shown to be associated with several regulators of transcription, including TFIID and Swi/Snf complexes. First identified as a nuclear serine/threonine kinase, Brd2, like other bromodomain proteins, is thought to function in mammalian development by regulating chromatin structure and transcription. Brd2 has been shown to bind to histone H4 via acetylated Lys12, a substrate of several histone acetyltransferase transcriptional coactivators.
Abbreviation
Phospho-BRD2 (S37)
UniProt
P25440
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human BRD2 (phospho S37) fragment
Target
RNF; BRD; FSRG; RING; KIAA; BRD2-IT; BRD2; BRD2-IT1; D6S113E; FSH; FSRG1; NAT; O27.1.1; RING3; RNF3; KIAA9001
Clonality
Monoclonal,Recombinant
Clone
A809
Conjugation
Unconjugated
Applications
WB
Field of Research
Cell Biology; Signal Transduction; Epigenetics and Nuclear Signaling
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:4000-1:20000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
88 kDa
Observed Molecular Weight
110 kDa
Isotype
IgG, κ
Available Sizes
Frequently Asked Questions
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