Recombinant Phospho-IKB alpha (Ser32, Ser36) Monoclonal Antibody

NF-kappa-B inhibitor alpha (IKB alpha) inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, IKB alpha becomes phosphorylated promoting itself ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

EDAID; MAD; IKBA; MAD-3; NFKBI; IKB alpha; NFKBIA; EDAID2; I kappa B alpha; IkappaBalpha; I-kappa-B-alpha; IKBalpha; IkB-alpha; MAD 3; NF kappa B inhibitor alpha; MAD3; alpha; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; Nuclear factor of kappa light chain gene enhancer in B cells; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor; pIκBα