Recombinant Phospho-YAP1 (Ser127) Monoclonal Antibody

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.

COB; COB1; YAP; YAP2; YAP65; YKI; YAP1;65 kDa Yes associated protein;65 kDa Yes-associated protein; Basic protease inhibitor; BPTI; Pancreatic Trypsin Inhibitor; Trasylol; YAp 1; YAP 65; Yes associated protein 1; Yes associated protein 1 65kDa; Yes associated protein 2; yes associated protein beta; yes -associated protein delta; Yorkie homolog