Recombinant DNMT3B Monoclonal Antibody
Product Specifications
Background
The DNMT3 family consists of two active methyltransferases, DNMT3A and DNMT3B, along with a DNMT3-like protein known as DNMT3L.DNMT3B plays a crucial role in regulating specific DNA methylation patterns, particularly during de novo methylation. It may function as atranscriptional corepressor by associating with CBX4 independently of DNA methylation. Mutations in the DNMT3B gene lead toImmunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
Abbreviation
DNMT3B
UniProt
Q9UBC3
Host
Rabbit
Reactivity
Human
Immunogen
Peptide. This information is proprietary to PTMab.
Target
DNMT3B; ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB|DNA cytosine-5 methyltransferase 3 beta|DNA methyltransferase HsaIIIB; M.HsaIIIB
Clonality
Monoclonal,Recombinant
Clone
A790
Conjugation
Unconjugated
Applications
WB; ChIP
Field of Research
Epigenetics and Nuclear Signaling
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
6
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
96 kDa
Observed Molecular Weight
96 kDa
Isotype
IgG, κ
Available Sizes
Frequently Asked Questions
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