Recombinant NELF-B Monoclonal Antibody
Product Specifications
Background
NELF-B is an essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNApolymerase II. The NELF complex causes transcriptional pausing and is counteracted by the P-TEFb kinase complex. It may be able toinduce chromatin unfolding. NELF-B is a modulator of ligand dependent and independent expression of estrogen receptor-α target genes.NELF-B expression is reduced in metastatic and recurrent breast cancer, suggesting that low levels of NELF-B in breast cancers may serveas an indicator for poor prognosis.
Abbreviation
NELF-B
UniProt
Q8WX92
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Peptide. This information is proprietary to PTMab.
Target
KIAA; COBRA; NELFB; COBRA1; NELF-B; KIAA1182
Clonality
Monoclonal,Recombinant
Clone
A786
Conjugation
Unconjugated
Applications
WB; IHC; FCM; IP
Field of Research
Epigenetics and Nuclear Signaling
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:10000-1:20000; IHC 1:100; FCM 1:100; IP 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
66 kDa
Observed Molecular Weight
70 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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