Recombinant SMARCC2/BAF170 Monoclonal Antibody
Product Specifications
Background
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) .Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by alteringDNA-histone contacts within a nucleosome in an ATP-dependent manner. BAF170 is one of the core subunits of the SWI/SNF complex, which is necessary for efficient nucleosome remodeling by Brg1 in vitro. While BAF170 has been shown to be part of the SWI/SNF complexin non-pluripotent cells, it is absent in pluripotent embryonic stem (ES) cells. Research studies have shown that expression of BAF170 is upregulated in neurons/neuronal progenitors upon differentiation of mouse ES cells with retinoic acid, and exogenous expression of BAF170leads to loss of stem cell pluripotency and self renewal.
Abbreviation
SMARCC2/BAF170
UniProt
Q8TAQ2
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Peptide. This information is proprietary to PTMab.
Target
Rsc; BAF; CRACC; SMARCC; SMARCC2; BAF170; CRACC2; Rsc8
Clonality
Monoclonal,Recombinant
Clone
A785
Conjugation
Unconjugated
Applications
WB; IHC; FCM; IP
Field of Research
Epigenetics and Nuclear Signaling
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000-1:2000; IHC 1:500-1:1000; FCM 1:100; IP 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
133 kDa
Observed Molecular Weight
170 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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