Recombinant SIN3A Monoclonal Antibody
Product Specifications
Background
OnBackground Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYConcogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperativelywith OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for thetranscriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for corticalneuron differentiation and callosal axon elongation.
Abbreviation
SIN3A
UniProt
Q96ST3
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Peptide. This information is proprietary to PTMab.
Target
SIN3A; WITKOS
Clonality
Monoclonal,Recombinant
Clone
A779
Conjugation
Unconjugated
Applications
WB; IHC; IP
Field of Research
Epigenetics and Nuclear Signaling; Cancer; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000-1:2000; IHC 1:100-1:1000; IP 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
145 kDa
Observed Molecular Weight
150 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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