Recombinant ATP Citrate Lyase Monoclonal Antibody
Product Specifications
Background
ATP-citrate lyase (ACL) is a homotetramer that catalyzes the formation of acetyl-CoA and oxaloacetate (OAA) in the cytosol, which is the keystep for the biosynthesis of fatty acids, cholesterol and acetylcholine, as well as for glucogenesis. Nutrients and hormones regulate theexpression level and phosphorylation of ATP-citrate lyase. It is phosphorylated by GSK-3 on Thr446 and Ser450. Ser455 of ATP-citrate lyasehas been reported to be phosphorylated by PKA and Akt. Phosphorylation on Ser455 abolishes the homotropic allosteric regulation by citrateand enhances the catalytic activity of the enzyme.
Abbreviation
ATP Citrate Lyase
UniProt
P53396
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Peptide. This information is proprietary to PTMab.
Target
OTTHUMP; ACLY; ACL; ATPCL; CLATP; ATP citrate (pro-S) lyase; ATP citrate lyase; ATP citrate synthase; ATP-citrate (pro-S-) -lyase; ATPcitrate synthase; ATP-citrate synthase; Citrate cleavage enzyme; OTTHUMP00000164773
Clonality
Monoclonal,Recombinant
Clone
A772
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Signal Transduction; Cancer; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000; IHC 1:500
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
120 kDa
Observed Molecular Weight
125 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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