Recombinant C5 Monoclonal Antibody
Product Specifications
Background
C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190kDa glycoprotein consisting of a disulphide linked alpha-chain (115kDa) and beta-chain (75kDa) . C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha chain) .
Abbreviation
C5
UniProt
P01031
Host
Rabbit
Reactivity
Human
Immunogen
Peptide. This information is proprietary to PTMab.
Target
Complement C; CPAMD; C5a; C5a anaphylatoxin; C5Da; Complement C5; ECLZB; C5; CPAMD4
Clonality
Monoclonal,Recombinant
Clone
A734
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Immunology; Signal Transduction; Cell Biology; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000; IHC 1:1000-1:2000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
188 kDa
Observed Molecular Weight
125 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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